【摘要】 目的研究肝硬化扩散加权成像ADC值的变化、机制及其病理基础。方法对11例经病理证实的肝硬化病人和12例正常肝脏行扩散加权成像并测量ADC值,DWI序列所选用b值分别为0、50、1000s/mm2。在b=50s/mm2及b=1000s/mm2计算得到ADC1及ADC2;测量结果与病理表现对照。结果肝硬化平均ADC1、ADC2均显著低于正常肝脏。病理表现为广泛纤维组织增生、小叶结构紊乱和假小叶形成。结论肝硬化组织ADC值降低原因可能为:①肝内纤维组织限制了水分子的活动,②肝实质内血流灌注减少。更多还原

【Abstract】 Objective To investigate the change and mechanism of ADC value in cirrhotic liver and its pathological basis. Methods Diffusion weighted imaging was performed in 12 normal liver and 11 patients with pathologically proved liver cirrhosis, and the ADC values of the liver were measured. The b values were 0, 50, 1000 s/mm2. The ADC₁ and ADC₂ were calculated with different b values. The findings were compared with pathology. Results The mean ADC₁, ADC₂ in cirrhotic liver was significantly lower than that in normal liver. The main histopathological changes were fibrous tissue proliferation, distortion of lobules and pseudolobular formation. Conclusion The main causes of decreased ADC value in cirrhotic liver were: ①the fibrous tissue in the liver limited the movement of water, ②the blood perfusion in the liver decreased.更多还原