【摘要】 目的通过测量四氯化碳诱导的大鼠肝纤维化及肝硬化的肝脏超声背向散射积分(IBS)并与病理对照,探讨超声背向散射积分定量评价大鼠肝纤维化、肝硬化的价值。方法测量正常大鼠及四氯化碳作用下的大鼠肝脏近场及远场IBS参数平均值(AII)及校正AII(AII%)。同时取病理且按照病理诊断将测量结果分组为正常对照组、肝纤维化组、肝硬化组。结果肝纤维化组AII、AII%值(27.59±1.19;55.55±2.31)、肝硬化组AII、AII%值(30.06±2.11;60.45±4.17)均高于对照组(17.80±1.92;36.83±4.14),差异显著(P<0.01);肝硬化组AII、AII%值高于肝纤维化组且有显著差异(P<0.01);各组近场及远场肝脏IBS参数及其标化值对比无统计学意义(P>0.01)。结论超声背向散射积分技术能早期发现肝纤维化且定量评价肝纤维化、肝硬化。更多还原

【Abstract】 Objective To discuss the quantitative assessment of hepatic fibrosis and cirrhosis of rats induced by CCl₄ using ultrasonic integrated backscatter （IBS） and compare with pathological features. Methods Liver’s IBS parameters of normal rats and those of injected CCl₄ were measured by AII and AII%. All data were divided into three groups according to the pathologic standard: control group, hepatic fibrosis group and cirrhosis group. Results AII and AII% of case group were higher than those of control groups （P<0.01）. AII and AII% of cirrhosis group were higher than those of hepatic fibrosis group （P<0.01）. Conclusion Ultrasonic IBS can detect hepatic fibrosis early, which is able to quantitatively evaluate hepatic fibrosis and cirrhosis.更多还原