【摘要】 目的:比较舍曲林和阿米替林治疗抑郁症的疗效及不良反应。方法:选择符合中国精神疾病分类方案与诊断第3版有关抑郁发作诊断标准的患者60例,随机分成2组:舍曲林组(30例)和阿米替林组(30例)。分别口服舍曲林20mg·d-1和阿米替林50mg·d-1,依病情可以调整40mg·d-1和250mg·d-1,用HAMD、TESS分别进行病情和副反应评定。结果:舍曲林和阿米替林的抗抑郁起效时间及疗效相近,舍曲林组有效率76.7%,阿米替林组为70.0%(P>0.05),舍曲林主要不良反应是食欲减退和恶心呕吐。结论:舍曲林的抗抑郁作用与阿米替林相似,但不良反应轻,用药方便,对海洛因依赖者脱毒后期出现的抑郁有一定的治疗价值。更多还原

【Abstract】 Objective: To compare the antidepressant effects and adverse reactions of sertraline and amitriptiline in treating depression. Methods: 60 patients meeting the CCMD-3 diagnostic criteria for depression episode were randomly divided into two groups. Thirty patients were treated with sertraline with starting dose of 20 mg·d-1, increased to 40 mg·d-1 p.o. The other thirty patients were treated with amitriptiline with starting dose of 50mg.d-1, then 250 mg·d-1 p.o. The patients were scored using HAMD and TESS. Results: The overall effective rate of sertraline and amitriptiline were 76.7% and 70.0%, respectively. The adverse reactions of sertraline were lighter than those of amitriptiline. The major adverse reactions of sertraline were anorexia and nausea. Conclusion: The antidepressant effects of sertraline and amitriptiline are similar, but adverse reactions of sertraline are lighter and more convenient to administer.更多还原