【摘要】 目的:了解四川省凉山彝族自治州西昌市静脉吸毒人群死亡率及死因。方法:于2002年11月招募静脉吸毒人群前瞻性研究队列376人,调查其社会人口学、吸毒行为和性行为特征。计算静脉吸毒人群随访2年的死亡率和死因构成,对其影响因素采用单因素和多因素Cox回归模型分析。结果:在队列2年随访中,死亡39人,死亡率为55.30/1000人年(95%CI:37.95-72.66),标准化死亡比为34.53(95%CI:21.60-54.54)。吸毒过量占全部死因的66.7%(26/39)。多因素Cox回归模型分析未见与全因死亡关系有统计学意义的变量;但见吸毒年限(≥9年)与吸毒过量死亡有统计学关联(P=0.0347),其危险比是2.31(95%CI:1.06-5.04)。结论:吸毒过量是西昌市静脉吸毒者的主要死因,需进一步探讨吸毒过量死亡的影响因素及其干预对策。更多还原

【Abstract】 Objective: To survey the mortality of injecting drug users (IDUs) in Liangshan of Sichuan Province. Methods: In November 2002, a community-based survey was conducted to recruit 376 IDUs for a prospective cohort study. Socio-demographics and high risk behavior at baseline was collected by interview questionnaire. Factors associated with the mortality rate in the two-year follow-up study were analyzed using Cox regression model. Results: A total of 39 deaths were found during the two-year follow-up study. The Mortality rate of the cohort was 55.30 per 1 000 years (95% CI: 37.95-72.66) with the standardized mortality ratio (SMR) as 34.53 (95% CI: 21.60-54.54). Out of the 39 deaths, 66.7% (26/39) were caused by heroin overdoses. No variables were found to be associated with death of all causes, but heroin abuse history (≥ 9 years) was found to be associated with overdose-related mortality in the final Cox regression model. The hazard ratio was 2.31 (95% CI: 1.06-5.04). Conclusion: Overdose served as the most frequent cause of deaths in Liangshan of Sichuan Province. Future studies should be conducted to focus on mortality and risk factors associated with mortality among IDUs to provide targeted interventions in reducing unnatural mortality.更多还原