【摘要】 目的:了解静脉吸毒人群前瞻性队列研究2年随访的HIV血清抗体阳转率和保持率情况。方法:于2002年11月,在四川省西昌市从社区招募了HIV血清抗体阴性的静脉吸毒人群前瞻性研究队列333人,队列每6个月随访1次和采集血样进行HIV抗体检测,以及分析队列本底的静脉吸毒人群社会人口学和HIV高危行为特征与队列保持率的关系。结果:静脉吸毒人群队列研究2年随访的HIV血清抗体阳转率为2.53/100人年(95%CI,1.10-3.97)和保持率为75.7%(252/333)。在多因素logistic回归模型分析中,与队列保持率的关系有统计学意义的变量为:彝族(OR,0.52;95%CI,0.29-0.91)、6个月回访(OR,4.72;95%CI,2.69-8.28)、和近3个月静脉吸毒频率高(OR,2.06;95%CI,1.12-3.80)。结论:本研究队列静脉吸毒人群HIV血清抗体阳转率较高和彝族静脉吸毒人群队列保持率低。更多还原

【Abstract】 Objective: To investigate the HIV seroconversion and cohort retention in a 2-year follow-up study among injection drug users (IDUs). Methods: In November 2002, a community-based baseline survey was conducted to recruit 333 HIV-seronegative IDUs for a prospective cohort study in Xichang City of Sichuan Province. Follow-up visits were conducted every 6 months to analyze risk factors associated with cohort retention for subjects’ baseline demographic and behavioral characteristics, and blood specimens were also collected to test for antibodies against HIV. Results: During the 24-month follow-up period, HIV incidence and cohort retention rate were 2.53 per 100 person-year (95% confidence interval [CI]:1.10, 3.97) and 75.7%, respectively. Multivariate logistic regression model showed that risk factors were significantly associated with cohort retention included Yi nationality (OR, 0.52; 95%CI, 0.29-0.91), appearing at the 6-month follow-up visit (OR, 4.72; 95%CI, 2.69-8.28), and drug injection in the past 3 months ≥ 6 times/day (OR, 2.06; 95%CI, 1.12-3.80). Conclusion: The study showed HIV seroconversion was high and cohort retention of Yi nationality was low in this cohort, respectively.更多还原