【摘要】 目的:研究海马中5-羟色胺(5-HT)对大鼠慢波睡眠的影响。方法:采用脑立体定位、核团微量注射和多导睡眠描记技术。结果:5-HT前体5-羟色胺酸(5-HTP)引起慢波睡眠(SWS)和总睡眠时间(TST)增多,觉醒(W)减少;非特异性5-HT受体阻断剂麦角新碱(MS)对睡眠无直接影响,但可完全阻断5-HTP的促睡眠效应。结论:海马中5-HT具有促睡眠效应。更多还原

【Abstract】 Objective: To study serotonin(5-HT) in the hippocampus on sleep.Methods: Stereotaxic surgery,microinjection and polysomnography(PSG).Results: Microinjection of 5-hydroxytryptaphan(5-HTP),the immediate precursor of 5-HT, into the hippocampus,enhanced slow wave sleep(SWS)and total sleep time(TST), but decreased W.Microinjection of methlysergide(MS),an antagonist of 5-HT receptor,into the hippocampus,had no direct effect on sleep,but abolished the SWS-promoting effect of 5-HTP completely.Conclusion: 5-HT promotes SWS in the hippocampus.更多还原