【摘要】 目的:从分子水平探测中药治疗肝纤维化的作用及机制。方法:利用CCL4复合因素建立SD大鼠肝纤维化模型。实验动物分成正常对照、模型、中药治疗三组,分别检测各组生化、肝纤维化指标和肝组织中ALR mRNA表达变业。结果:1.ALT、AST、A/G、HA、PCⅢ、LN、PLD各指标:模型组均高于对照组(P<0.01),中药治疗组低于模型组(P<0.01),并且,HA、PCⅢ、LN、PLD的降低与病理组织反应肝纤维化的好转程度一致;2.肝组织中ALR mRNA的相对表达量:中药治疗组、模型组明显高于对照组(P<0.01),中药治疗组高于模型组(P<0.01)。结论:联联合检测生化、肝纤维化指标可提高肝纤维化早期诊断;肝纤维化时肝组织ALR mRNA的高表达可逆转肝纤维化。更多还原

【Abstract】 Objective:To sutdy the molecular mechanism of treatment by Chinese herbs on the hepatic fibrosis of rats.Methods:Hepatic fibrosis model of rats were established with CCL₄.Then the rats were divided into control,model and Chinese herbs treated groups.The elevel of ALR mRNA expression,biochemical and hepatic fibrosis paparmeters were observed from different groups.Results:The concentrations of ALT、AST、A/G、HA、LN、PLD and PCⅢ in serum are 1.model group higher than control （P<0.01）,2.Chinese herbs treated group lower than model group（P<0.01）.更多还原