【摘要】 目的:探讨定心胶囊对房颤大鼠血小板活化指标TXB2、PAI-I的影响,研究开发中药治疗房颤及预防房颤后血栓。方法:采用氯化钙-乙酰胆碱混合液以鼠尾静脉给药的方式建立房颤的动物模型。筛选典型房颤心电图表现的大鼠30只,随机分为AF模型组、定心胶囊治疗组、维拉帕米对照组及正常组,共4组。定心胶囊治疗组、维拉帕米对照组给药治疗4周后,测定血清中TXB2、PAI-I的含量。结果:①治疗组与模型组比较,治疗组血清中TXB2、PAI-I的含量明显降低,P均<0.05,有统计学意义;②定心胶囊治疗组与西药对照组使房颤大鼠血清中TXB2、PAI-I的含量均降低,中药组优于西药组。结论:定心胶囊能降低血清中TXB2、PAI-I的含量,降低血小板活化,是防治房颤后血栓的有效药物。更多还原

【Abstract】 Objective:To develop the effective therapy for atrial fibrillation（AF）,and study the mechanisms of Dingxin capsule.To elucidate the role of thromboxane B-2（TXB₂） and plasminogen activator inhibitor-I（PAI-I） in the pathogenesis of AF.Methods: 36 rats were randomized to 4 groups: normal control group,model group,Dingxin capsule group,Verpamil intervention group.The level of TXB₂ and PAI-I of AF rats were measured.Results: With the comparison of treating group and model group,the level of TXB₂ and PAI-I in treating group lowed obviously（P<0.05）.Both of them had statistic significance.Both Dingxin capsule group and Verpamil intervention group could low the level of TXB₂ and PAI-I,but Dingxin capsule group is better.Conclusion: TXB₂ and PAI-I played important role in the pathogenesis of AF.Dingxin capsule could correct the level of TXB2 and PAI-I in AF rats.更多还原