【摘要】 为了充分利用人参资源,寻找新型高效低毒的抗肿瘤药物,我们采用肿瘤细胞染色计数法(MTT法)比较了三种新的人参二醇脂肪酸酯衍生物[3β-乙酰氧基人参二醇(Ⅰ)、3β-棕榈酸酰氧基人参二醇(Ⅱ)、3β-硬脂酸酰氧基人参二醇(Ⅲ)]和人参二醇的抗肿瘤活性。所用癌株为绿猴肾癌株(Vero);阳性对照为5-氟尿嘧啶;空白对照是5%新生牛血清的RPM I1640培养基;阴性对照为与配药所用相同比例的溶剂和培养基。结果:化合物Ⅰ抗肿瘤活性最强,其次为人参二醇,Ⅱ和Ⅲ抗肿瘤活性最弱且两者活性相当;人参二醇脂肪酸酯衍生物抗肿瘤活性与浓度呈正相关,但与脂肪酸分子量无关。更多还原

【Abstract】 For making use of Ginseng resources and finding new anti-tumor drugs, the anti-tumor activity of three kinds of new panaxadiol fatty acid ester derivates: 3β-acetoxy panaxadiol(Ⅰ),3β-palmitic acid aceloxy panaxadiol(Ⅱ),3β-octadecanoic acid aceloxy panaxadiol(Ⅲ) and panaxaiol were compared through the method of cell stain and counting.Tumor cell was Vero cell line.Positive control was 5-FU.Blank was RPMI1640 culture medium.Negative control was RPMI1640 culture medium and the solvent for subjected drugs.The result showed that compound I had the strongest anti-tumor activity,second was panaxadiol,Ⅱ and Ⅲ had the same and the weakest antitumor activity.Furthermore,the anti-tumor activities of panaxadiol fatty acid ester derivates showed positive correlation with subjects’ concentrations, but no relationship with molecular weight of fatty acid.更多还原