【摘要】 目的:观察中医四步疗法治疗慢性乙型肝炎的临床疗效。方法:将符合入选标准的慢乙肝轻、中度患者120例随机分为研究组80例、对照组40例,研究组根据ALT水平将患者分为免疫介入轻、中、重3度,运用中医辨证论治分四步治疗。对照组采用拉米夫定100mg,口服,每日一次,连服两年。结果:研究组HBeAg、HBV-DNA转阴率、HBV-DNA前C区变异转阴率、完全应答率分别为58.9%、57.5%、78.9%、45%,对照组分别为33.3%、55%、38.9%、35%,两组相比具有显著差异(p<0.05)。研究组治疗后,肝纤四项指标值较治疗前均明显下降,研究组治疗效果优于对照组。经中医四步法治疗后,治疗过程中ALT水平升高,之后随病毒指标转阴而降至正常,ALT升高患者中药应答率较不升高患者的中药应答率明显升高。结论:中医四步疗法治疗慢性乙型肝炎具有较好的临床疗效。更多还原

【Abstract】 Objective: To observe the clinical curative effect of chronic hepatitis B treated by the four-step therapeutics of Traditional Chinese Medicine(TCM).Methods:120 patients with mild or moderate Chronic Hepatitis B(CHB) were randomly divided into two groups :80 patients in treatment group and 40 in control group.All enrolled cases accorded with the enroll standard.In treatment group,the patients were divided into mild moderate and severe degree of immune intervention based on the ALT level and treated with four-step therapeutics according to the dialectical theory.In control group,all patients were administered 100mg Lamivudine orally daily for two years.Results:The loss rates of HBeAg,HBV-DNA,precore mutation were 58.9%,78.9% in treatment group respectively,and 33.3%,38.9% in control group.There were significant defferences between them.The total effectiveness ratio of two groups has no significant difference.After the treatment,the value of HA,PCIII,IV.C,LN decreased dramatically in treatment group and the anti-hepatic fibrosis results of treatment group were superior to those of control group.The four-step therapeutics of TCM could improve the ALT value and the ALT value declined to normal after the virus indexes’loss.The response rate in treatment group of ALT-elevating patients was higher than those of no ALT-elevating patients.Conclusion:The four-step therapeutics of TCM is effective in treating the CHB patients.更多还原