【摘要】 目的:观察60例急性心肌梗死（AMI）患者在发病早期应用前列地尔脂微球载体注射液（Lipo-PGE₁）治疗对QTc离散度（QTcd）的影响。方法:60例AMI患者随机分为前列地尔治疗组（n=31）和对照组（n=29）。治疗组在常规治疗基础上加用Lipo-PGE₁,疗程3周;对照组只采用常规治疗方法。记录每例患者入院后用药前和用药后第1,2,3,12,24 h和d3的12导联心电图测定QTcd。结果:入院后给药前测定QTcd治疗组与对照组间差异无显著性[（87．2±125）vs（86．9±11．3）ms,P＞0．05],前壁与下壁梗死之间QTcd差异无显著性[（87．2±12．5）vs （86．7±12．1）ms,P＞0．05]。治疗组在用Lipo-PGE₁2 h时QTcd较对照组开始显著降低[（78．5±12．6）vs（87．8±13．6）ms,P＜0．05],24h起QTcd较对照组极显著降低[（66．3±11．3）vs（88．1±13．2）ms,P＜0．01]。治疗组有8例出现室性心律失常,在应用Lipo-PGE₁2h后7例消失。结论:Lipo-PGE₁在AMI发病早期应用可降低QTcd,从而减少恶性心律失常发生,减少AMI的死亡率。更多还原

【Abstract】 Objective:To evaluate the prophylaxis of QT intervals dispersions （QTcd） with al- prostadil injections （Lipo-PGE₁） in patients with initial stage of acute myocardial infarction （AMI）. Methods:60 AMI inhospitalized patients were randomly treated with either conventional regimen （n= 29） or conventional regimen plus alprostadil injection （n=31） for 3 weeks.The patients underwen| a 12-lead ECG to monitor the QTcd pre-therapy and in 1,2,3,12,24 hours and day 3 post-therapy. Results:Compared to the conventional therapy of （87.8±13.6） ms,the patients adding on PGE₁ initia- ted the significant reduction of QTcd in 2 hours post-therapy （78.5±12.6）ms.（P＜0.05）.The QTcd of the patients injecting PCE₁ was （66.3±11.3） ms in 24 hours post-therapy,compared with the con- ventional therapy of （88.1±13.2） ms （P＜0.01）.The PGE₁-treated patients experienced ventricular arrhythmias （8 out of 31 patients）,of which 7 incidences were recovered when patients continued the PGE₁ therapy for more than 2 hours.Conclusion:Administration of alprostadil at the early stage of AM1 episode was beneficial in the reduction of the incidence of malignant arrhythmia and mortality due to AMI.更多还原