Objective: To establish a LC-MS-MS method for quantification and pharmacokinetics of flunarizine in healthy volunteers. Methods: The blood samples from 32 healthy subjects after iv infusion of single-dose (2.5,10 or 15 mg) and multi-doses (10 mg) extracted by hexane: isopropanol were quantified by a Shimadzu C18 I. D column (150 mm×4. 6 mm,5μm) and a mobile phase consisted of 25% 0. 01 mol·L-1 ammonium acetate buffer ( pH 3. 5) and 75% methanol and detection with LC-MS-MS. Results: A calibrated linear curve...
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