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高效液相色谱法测定复方苦参肠炎康胶囊中苦参碱的含量

Quantification ot matrine in compound capsules of Sophorae flavescentis for relieving enteritis by HPLC

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【作者】 屠万倩张留记李向阳

【Author】 TU Wan-qian,ZHANG Liu-ji , LI Xiang-yang (Henan Academy of Chinese Traditional Medicine, Zhengzhou 450004 , China; Department of Chemistry, Zhengzhou University, Zhengzhou 450001 , China; Henan Institute of Food & Drug Quality Control, Zhengzhou 450003 , China)

【机构】 河南省中医药研究院郑州大学化学系河南省食品药品检验所 郑州 450004郑州 450001郑州 450003

【摘要】 目的:建立复方苦参肠炎康胶囊中苦参碱的含量测定方法。方法:采用HPLC法,Hypersil NH2柱(250 mm×4.6 mm,5μm),乙腈-无水乙醇-0.1 mol·L-1磷酸溶液(93:3.5:3.5)为流动相,检测波长为205 nm。结果:苦参碱在0.16~0.80μg呈良好的线性关系(r=0.999 6);苦参碱平均回收率为97.26%,RSD为2.1%。结论:该方法简便准确,重现性好,可用于复方苦参肠炎康胶囊的质量控制。

【Abstract】 Objective: To establish a HPLC method for quantification of matrine in compound capsules of Sophorae flavescentis for relieving enteritis ( Fufang Kushen Changyankang Capsules ) . Methods: The HPLC condition was consisted of a Hypersil NH2 column(250 mm×4.6 mm,5μm) , a mobile phase of acetonitrile-ethanol-0.1 mol·L-1 H3PO4(93:3. 5:3. 5)and a detection wavelength at 205 nm. Results:The linearity of matrine concentration curve was in a range of 0. 16 - 0. 80μg( r = 0. 999 6). The average recovery of matrine was 97. 26% ( RSD =2. 1% ). Conclusion: The HPLC method is used for the quality control of Fufang Kushen Changyankang Capsules.

  • 【文献出处】 中国新药杂志 ,Chinese Journal of New Drugs , 编辑部邮箱 ,2006年20期
  • 【分类号】R286
  • 【被引频次】4
  • 【下载频次】103
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