【摘要】 目的:了解瑞波西汀治疗老年期抑郁障碍的疗效及不良反应。方法:60例老年期抑郁障碍患者分成两组,瑞波西汀组30例,给予瑞波西汀4～8 mg·d-1;氟西汀组30例,给予氟西汀20～40 mg·d-1;观察4周,评定疗效。结果:瑞波西汀组总有效率80．00％,氟西汀组总有效率70．00％,和疗前比较两组统计学处理均有显著性差异(P< 0．01),药物不良反应基本相当。结论:瑞波西汀是一种有效、安全的抗抑郁药物,有改善睡眠的作用,不良反应轻。更多还原

【Abstract】 Objective:To evaluate the efficacy and safety of reboxetine versus fluoxetine in the elder patients with depression. Methods:60 patients who met the diagnostic criteria of depression of CC-MD-3 were randomly treated with reboxetine (4 -8 mg) or fluoxetine (20 - 40 mg) daily for 4 weeks. The efficacy and safety of therapy was assessed based on HAMD, CGI and TESS before and after treatment. Results:The effective rate of reboxetine versus fluoxetine was 80.00% versus 70.00% (P > 0. 05 ). The side effects incidence of reboxetine showed no statistical difference from fluoxetine. Conclusion: Reboxetine offers effective and safe therapeutic option for geriatrics with depression.更多还原