节点文献

多巴胺D₃受体部分激动剂BP897的合成

Synthesis of BP897 as a dopamine D₃ receptor partial agonist

推荐 CAJ下载
PDF下载
不支持迅雷等下载工具，请取消加速工具后下载。

【Author】 CAI Jin ,GU Li-jie,ZHOU Wen ,HUA Wei-yi,JI Min (Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China;Institute of Pharmaceutical Engineering, Southeast University, Nanjing 210096, China;Medicine of Altitude Vocational School in Xuzhou, Xuzhou 221116 , China)

【机构】中国药科大学新药研究中心；东南大学制药工程研究所；江苏徐州医药高等职业学校徐州 221116；南京 210009；南京 210096；

【摘要】目的:合成多巴胺D,受体部分激动剂BP897。方法:以二羟乙基胺为起始原料,经过氯化、环合、取代、肼解、缩合等反应合成BP897。结果:以总产率为40．2％合成了多巴胺D,受体部分激动剂BP897,结构经核磁氢谱(1HNMR)、质谱(MS)和红外(IR)确证。结论:该法原料价廉易得,反应条件温和,收率较文献有所提高。更多还原

【Abstract】 Objective:To synthesize BP897, a dopamine D3 receptor partial agonist. Methods: Starting from diethanolamine, BP897 was prepared via chlorination, cyclization, substitution, aminolysis and condensation reaction. Results:The total yield was 40. 2% . The structure was verified by 1HNMR, MS and IR. Conclusion:A synthetic procedure with mild reactive conditions and cheaper starting rea gents for BP897 is achieved.更多还原