【摘要】 目的:探讨猫爪草不同提取物对移植性肝癌H₂₂小鼠的抗肿瘤作用。方法:采用系统溶剂法提取分离猫爪草获得石油醚、氯仿、乙酸乙酯、正丁醇和水5个提取物。建立移植性肝癌H₂₂小鼠模型后,检测各提取物灌胃给药10 d后的抑瘤率、生命延长率、肺脏指数、肝脏指数、脾脏指数和胸腺指数等。结果:石油醚提取物高、中、低剂量组对H₂₂小鼠的肿瘤生长均无明显的抑制作用。氯仿、乙酸乙酯、正丁醇提取物高、中、低剂量组的抑瘤率（%）依次分别为51．78,48．80,33．33;55．51,45．10,31．36;32．71,25．08,24．64;生命延长率（%）分别为10．58,60．09, 58．23;-1．05,56．91,45,09;60．98,59．76,50．84;水提物高、中、低剂量组的生命延长率（%）分别为74．98,74．76, 50．05。水提物可以增加脾脏指数和胸腺指数。结论:猫爪草氯仿、乙酸乙酯和正丁醇提取物具有一定体内抗肿瘤作用,而水提取物具有一定的免疫调节作用。更多还原

【Abstract】 Objective:To evaluate the effect of different extracts from Radix Ranunculus Ternate against transplant hepatic cancer in mice.Methods:The raw materials Radix Ranunculus Ternate were extracted by five solvents of petroleum ether,chloroform,ethyl acetate,n-butynol and aqueous solution, respectively.A model of H₂₂mice with transplant hepatic cancer was inoculated.After the H₂₂mice were fed with the five extracts（three concentrations each extract）for 10 days,the anti-tumor effects of the ex- tracts with regard of inhibitory rate,survival rate and weight indexes of lung,liver,spleen and thymus tissues were assessed.Results:The inhibitory rates（%）of low,middle and high concentrations of chloroform,ethyl acetate and n-butynol extracts were 51.78,48.80 and 33.33,vs.55.51,45.10 and 31.36 vs.32.71,25.08 and 24.64,respectively,the survival rates（%）were 10.58,60.09 and 58.23 vs.-1.05,56.91 and 45.09 vs.60.98,59.76 and 50.84,respectively.The aqueous solutions （low,middle and high concentrations）showed a survival rate（%）of 74.98,74.76 and 50.05,respec- tively,and improved spleen and thymus indexes.Conclusion:The chloroform,ethyl acetate and n-bu- tynol extracts from Radix Ranunculus Ternati were effective against tumors in the H₂₂mice and aqueous extracts showed immune modulation.更多还原