【摘要】 目的:研究妇科消炎0号颗粒剂的提取工艺。方法:用正交试验法分别对莪术油的提取及包结工艺、酒大黄等其余3味药的提取工艺进行优选。结果:优选得到的提取工艺参数为:莪术粗粉,单独加莪术粗粉质量8倍的水,浸泡8 h,水蒸汽法提取挥发油6 h;莪术挥发油用饱和水溶液法包结,加莪术挥发油8倍体积的β-环糊精,加60倍体积的水,搅拌1 h;酒大黄等其余3味加60%乙醇8倍体积,提取3次,每次1 h,提取液过滤,滤液减压回收乙醇后,加入莪术煮提液,共浓缩,浓缩液真空干燥成干粉,与挥发油包结物混匀后,加入辅料,制成颗粒。结论:优选的工艺能最大限度提取药物有效成分,并能最大限度减少药物有效成分的损失。更多还原

【Abstract】 Objective:To optimize the extraction technique for the herbal granules against female inflammations(Fukexiaoyanlinghao pellet).Methods;The extraction procedures for active principles of the herbal materials made of the granules against female inflammations,including Rhizoma Curcumae, Radix et Rhizoma Rhei prepared with vino and other two components,were optimized by an orthogonal test.Results;The optimal procedures were as follows;Curcuma crude powders were soaked in water (1:8)for 8 hours and then distilled to extract the essential oils for 6 hours.The essential oils obtained was included by saturated aqueous solution and then stired withβ-cyclodextrin(1;8)and water(1:60) for 1 hour;the Radix et Rhizoma Rhei prepared with vino and other two herbal components were extrac- ted with 60% alcohol(1;8)three times,and each time for 1 hour.The liquor extractions were filtered and mixed with the aqueous extraction of curcuma.The mixed solution was concentrated and dried in vac- uum to make concentrated powders.The concentrated powders were blended with the inclusion complex of the curcuma oil to make the granules.Conclusion;The extraction procedure may maximally remain the active ingredients of the herbal materials.更多还原