【摘要】 目的探讨食管基底细胞样鳞癌(basa lo id squam ous carc inom a,BSC)的临床病理及预后特点。方法回顾我科2000年7月至2003年5月1 257例行根治性切除手术的食管癌患者的临床资料,检索出BSC 18例(BSC组),随机抽取同期手术的传统食管鳞癌(esophagea l squam ous carc inom a,ESC)患者54例作为对照(ESC组),对比分析两组患者年龄、性别构成比、首发症状出现时间、TNM分期、术后生存时间、肿瘤复发率和转移率等。结果BSC组患者的发病年龄(61.56±7.62岁vs.56.11±10.58岁;t=-2.012,P=0.048),T4期患者的比率(27.8%vs.5.6%;χ2=6.750,P=0.020),术后肿瘤转移率(62.5%vs.25.0%,P=0.047)均高于ESC组,术后生存时间短于ESC组(P<0.05);而两组患者间性别构成比(P=0.494)、术后肿瘤复发率(P=0.887)差异无统计学意义。结论食管BSC发病年龄偏高,其肿瘤侵袭能力和转移能力均高于传统ESC。更多还原

【Abstract】 Objective To investigate the clinicopathological features and prognostic aspect of basaloid squamous carcinoma（BSC）.Methods From July 2000 to May 2003,the clinical data of（1 257） documented cases that underwent potentially curative resection on esophageal carcinoma in our department were retrospectively analysed,and 18 cases of BSC（BSC group） were detected.And 54 cases of typical squamous carcinoma of esophagus（ESC） were randomly selected as control（ESC group）,to analyse the clinicopathological and prognostic parameters of BSC patients.Results The age of BSC group patients was higher than that of ESC group（61.56±7.62 years vs.（56.11±）10.58 years;t=-2.012,P=0.048）,and the ratio of T₄ stage was much higher than that in ESC group（27.8% vs.5.6%;χ²=6.750,P=0.020）.The follow-up showed that,comparing with ESC group,the ratio of metastasis was higher（62.5% vs.25.0%,P=0.047）,and mean survival time（P<0.05） was significantly shorter in patients of BSC group after curative resection.There were no statisticaly differences in patient gender（P=0.494）,or ratio of recurrence（P=0.887） between two groups.Conclusion The BSC is a rare carcinoma involving esophagus,which occurs in elder patients.Both invasiveness and metastasis of BSC are more usual than those of typical ESC.更多还原