【摘要】 目的分析青少年屈光不正性弱视使用硬性透气角膜接触镜(rigid gas permeable,RGP)在三年中的视力矫正效果以及在屈光度、图形视觉诱发电位(pattern-visual evokedpotential,P-VEP)方面的变化及其机制。方法对23例年龄≥12周岁屈光参差性弱视患者[男10例15眼,女13例17眼,平均年龄为(15.26±2.01)岁]在实验配戴RGP始末分别测定屈光度、矫正视力和P-VEP;所有RGP实验对象配戴镜片周期>50周,且与同期20例青少年屈光不正性弱视框架镜验配者作对照。结果23例实验患者RGP验配适应时间为2~6 d不等。至实验结束,近视球镜度RGP组增加-0.36 Ds,柱镜度下降0.12 Dc;框架镜对照组球镜度加深-0.81 Ds;柱镜度无显著变化。实验末两组球镜度值比较,组间差值为0.55 Ds(配对t检验P<0.05)。矫正视力:RGP组与框架镜对照组实验前后自身对照,分别上升0.52±0.22和0.12±0.05(五分对数视力)。P-VEP检测:实验始末两组自身对照,P100波振幅无显著变化,P100波潜伏时两组分别缩短13 ms和8 ms,差异有显著性(配对t检验P<0.01)。结论年龄≥12周岁青少年屈光不正性弱视可选择性地使用RGP,以提高弱视眼的矫正视力。更多还原

【Abstract】 Objective To investigate the effects of wearing a rigid gas permeable contact lens（RGP） in teenage amblyopes who were older than 12 years and to study their refractive status and pattern-visual evoked potentials（P-VEP） during a longterm follow-up.Methods Twenty-three teenage amblyopes [15 eyes of 10 men,17 eyes of 13 women, average age（15.26±2.01）years] participated in the study.All of them had been examined to measure refractive power,visual acuity and P-VEP before and after RGPs were fitted.Each of them was requested to wear the RGPs for at least 50 weeks.As a control,the same testing was also done on another group of 20 teenagers who wore spectacles.Results 2～6 days were needed to adapt to the RGPs.During three years of follow-up,there was an average increase of-0.36 Ds in the spherical component of refraction in the RGP group,and-0.81 D in the spectacle group（paired t-test P<0.05）.Cylindrical power decreased-0.12 Dc on average in the RGP group but did not change in the control group.When compared to pre-fitting,it was found that the P-VEP was shorter in P₁₀₀ wave potential time（13 ms in the RGP group and 8 ms in the spectacle group,paired t-test P<0.01）,but there was only a slight increase in the amplitude of the P₁₀₀ wave.Conclusion Amblyopic teenagers can wear rigid gas permeable contact lenses on a daily basis.更多还原