【摘要】 目的:了解住院精神分裂症患者伴发非酒精性脂肪肝情况。方法:对228例住院精神分裂症患者进行肝脏B超检查,并检测其空腹血糖、血脂、ALT、GGT、AKP等代谢指标。结果:住院精神分裂症患者伴发非酒精性脂肪肝的比例为32.5%,伴脂肪肝者体重指数、腰围、臀围明显大于不伴脂肪肝者(27.5±3.4/23.7±3.3,96.8±8.5/86.7±10.0,102.5±13.1/96.0±7.1,F=62.62～20.01,P=0.000),而除载脂蛋白A外其它血脂指标均高于不伴脂肪肝者(如:TC:4.7±1.0/4.2±1.0,TG:2.2±1.4/1.5±0.8,LDL-ch:3.3±0.9/2.8±0.8)。女性、BMI值较大、病程长、TG高、ALT较高者与患脂肪肝有关(回归系数分别为:-1.217、0.349、0.053、0.601、0.061)。结论:长期住院的慢性精神分裂症患者伴发非酒精性脂肪肝的比例高,存在一些危险因素,值得临床关注。更多还原

【Abstract】 Objectives:To investigate the prevalence of non-alcoholic fatty liver disease among schizophrenia inpatients and to analyse its related factors.Methods:B ultrasound examinations in liver were conducted in 228 inpatients with schizophrenia,and serum chemical levels were measured,such as fasting blood glucose,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein AI(apoAI),apolipoprotein B(apoB),serum alanine aminotransferase(ALT),y-glutamyltransferase(GGT),and alkaline phosphatase(AKP).Results:the prevalence of comorbid non-alcoholic fatty liver disease among schizophrenia inpatients was 32.5%,which is significantly higher than that of general population.Compared with the patients without fatty liver disease,the patients with non-alcoholic fatty liver disease had higher BMIs(27.5±3.4/23.7±3.3),larger waist/hip circumference ratio(96.8±8.5/86.7±10.0,102.5±13.1/96.0±7.1),and more serious serum lipid metabolic disturbance(TC:4.7±1.0/4.2±1.0,TG:2.2±1.4/1.5±0.8,LDL-ch:3.3±0.9/2.8±0.8).Female,higher BMIs,longer disease duration,higher triglycerides and alanine aminotransferase might be the risk factors of non-alcoholic fatty liver disease in this population(with β of-1.217,0.349,0.053,0.601 and 0.061 respectively).Conclusions:Schizophrenia inpatients had higher prevalence of comorbid non-alcoholic fatty liver disease.更多还原