【摘要】 目的:观察甘草苷对慢性应激抑郁模型大鼠体重及行为学的影响。方法:72只成年SD雄性大鼠,随机分为6组:正常对照组、模型组、氟西汀组,以及甘草苷3个剂量组,每组12只。采用慢性应激加孤养造模,应激持续5周,从第3周起进行药物干预。观察大鼠体重及行为学改变。结果:应激5周后,与正常对照组相比模型组大鼠体重降低(429±45/494±37,P<0.01),糖水消耗量降低(8.3±3.3/14.4±2.7,P<0.01),强迫游泳的不动时间延长(96±10/37±9,P<0.01)。3周甘草苷灌胃后,大鼠体重仍低于正常对照组(444±45、442±22、423±28/494±37,P<0.01),但与模型组相比差异无显著性;甘草苷3个剂量组的糖水消耗量较模型组大鼠增加(11.4±4.0、14.1±3.5、14.0±2.5/8.3±3.3,P<0.05);强迫游泳不动时间较模型组大鼠也缩短(63±8、66±10、26±8、41±11/96±10,z=-2.02、-3.52、-3.03,P<0.05或P<0.01)。结论:除未发现对体重的影响外,3周灌胃甘草苷可以有效逆转抑郁模型大鼠上述的行为学改变,提示甘草苷具有抗抑郁样作用。更多还原

【Abstract】 Objective:To observe the effect of liquiritin on body weight and behavior in depression model rats.Methods:Seventy-two male Sprague-Dawley(SD)rats were randomly assigned into normal control group,model group(stress+vehicle),fluoxetine group(stress+ fluoxetine)and three liquiritin groups(stress+liquiritin at different dose).The behavior of rats was detected by sucrose consumption test and forced swimming test.Results:The model rats showed significantly lower body weight(429±45/494±37,P<0.01),sucrose consumption(8.3±3.3/14.4±2.7,P<0.01)and longer immobility time in forced swimming test(96±10/37±9).After 3 weeks treatment with liguiritin,the weight of rats was still lower than normal control(444±45,442±22,423±28/494±37),but had no significant difference to model rats.The sucrosec onsumptions of the three dosage groups were 11.4±4.0,14.1±3.5 and 14.0±2.5 respectvely,lighter than that of model rats(8.3±3.3).Immobility time in forced swimming of the 3 dosage groups were also shortened(63±8,66±10,26±8,41±11)compared to the model group(96±10).Conclusions:Three-week intragastric administration of liquiritin can recover the behavior changes of chronic stress rats but had no effect on body weight gain.This result suggests that liquiritin exert antidepressant-like effects comparable to those of fluoxetine in depression models.更多还原