【摘要】 目的:探讨未服药的精神分裂症患者和健康对照者面孔知觉的脑区激活的差异。方法:本研究对10名未服药的精神分裂症患者(患者组)和10名年龄、教育程度和性别匹配的健康人(对照组)进行面孔知觉测试,应用功能磁共振成像(fMRI)技术,比较两组脑区激活区域的差异。结果:两组的面孔知觉任务平均反应时差异无显著性(1.32±0.29/1.28±0.18),但患者组的正确率低于对照组(47.9±24.4/71.3±14.9,t=2.62,P<0.05)。与对照组相比,患者组在面孔知觉时双侧梭状回、左丘脑部位激活降低。结论:精神分裂症患者双侧梭状回、左丘脑功能低下,是其面孔知觉功能受损的影像学证据。更多还原

【Abstract】 Objective:To assess the brain functional areas for schizophrenic patients and healthy controls by face perception tests.Methods:Using functional magnetic resonance imaging(fMRI),we measured activation with the face perception of 10 schizophrenic patients and 10 matched healthy controls.Results:The two groups had no significant difference in reaction time(1.32±0.29/1.28±0.18).But schizophrenic patients had lower rate of correct reaction(47.7±24.4/71.3±14.9,t=2.62,P<0.05).Compared to healthy controls,schizophrenic patients showed significantly reduced activated regions in bilateral fusiform gyrus and left thalamus.Conclusion:The reduced activation of the bilateral fusiform gyrus and left thalamus provides a neuroimaging evidence of deficit in face perception of schizophrenic patients.更多还原