【摘要】 目的:探讨丙型肝炎(丙肝)患者感染途径与其肝脏病变程度的关系。方法:根据感染途径的不同将210例丙肝患者分输血后丙肝(PTHC组)102例和散发性丙肝(SHC组)108例,应用荧光定量聚合酶链反应(FQ-PCR)技术、酶联免疫吸附方法(ELISA)和自动生化速率法分别检测两组患者血清中HCV RNA含量、抗-HCV及ALT水平。结果:PTHC组HCV RNA阳性率和ALT的异常率均显著高于SHC组(χ2=23.39,P<0.01和χ2=13.73,P<0.01);HCV RNA阳性患者中,PTHC组的HCV DNA含量均值显著高于SHC组(t=4.29,P<0.01);ALT异常患者中,PTHC组的ALT水平均值显著高于SHC组(t=4.30,P<0.01)。HCV RNA的含量与ALT水平呈正相关(r=0.794,P<0.01)。结论:PTHC组患者病毒血症水平和肝脏功能损害的程度均显著高于SHC组,HCV不同的感染途径可导致患者不同的感染结果。更多还原

【Abstract】 Objective:To investigate the relationship between the degree of liver injury and the different infective mode of patients with hepatitis C.Methods:Patients with hepatitis C were divided into sporadic hepatitis C(SHC) and post transfusion hepatitis C(PTHC) by different infective mode.The quantify of HCV RNA in serum samples was detected by fluorescent quantitative polymerase chain reaction(FQ-PCR),the levels of anti-HCV and alanine transaminase(ALT) were detected by enzyme immunoassay(ELISA) and automatic biochemistry analyzer.Results:The positive rate of HCV RNA and the abnormal rate of ALT in PTHC wrer markedly higher than those in SHC(χ~2=23.39,P<0.01 and χ~2=13.73,P<0.01).The average concentration of HCV RNA among the patients of positive HCV RNA in PTHC were markedly higher than those in SHC(t=4.29,P<0.01),the average level of ALT among the patients of abnormal ALT in PTHC were markedly higher than those in SHC tively(t=4.30,P<0.01).The more copies of HCV RNA in blood samples,the higher the ALT levels(r=0.794,P<0.01).Conclusion:The levels of viral load and the degree of liver injury in PTHC are significantly higher than those in SHC,different infective mode with HCV can bring on different clinical effect.更多还原