【摘要】 目的探索vMIP-II结合趋化因子受体的活性位点以便有目的地对其进行改构。方法应用生物信息学方法对影响vMIP-II受体结合的氨基酸残基进行预测分析。结果vMIP-II对不同的受体有不同结合位点,其与CC类趋化因子受体结合位点主要在核心骨架,与CXC类趋化因子受体结合位点主要在N端。结论vMIP-II是一种极佳的趋化因子受体阻断剂类新药开发先导物。更多还原

【Abstract】 【Objective】 To explore the chemokine binding properties of vMIP-II and provide theory basis for further mutation analysis.【Methods】 Bioinformative method was used to analyze the binding residues of vMIP-II to different receptors.【Results】 vMIP-II had different specific residues for different receptors binding.Its core mainly contributes the binding to CC chemokines,while its N-terminus contributes the binding to CXC chemokines.【Conclusion】 It reveales a good drug template for developing new drug for multiple chemokine receptors blocking.更多还原