【摘要】 目的研究宫颈癌原发灶和盆腔非转移淋巴结中树突细胞(DC)浸润对临床预后影响。方法采用免疫组化SP法染色,显微测微尺检测85例宫颈鳞状细胞癌及相应119枚盆腔淋巴结中树突细胞的浸润密度。结果宫颈癌原发灶中DC浸润密度与临床分期、分化程度、盆腔淋巴结转移(P<0.05),与肿瘤组织淋巴管/血管浸润无关(P>0.05),宫颈癌原发灶和盆腔非转移淋巴结中DC浸润密度与临床预后相关。结论DC浸润反映了机体的免疫功能状态,检测DC的浸润密度可作为判定宫颈癌临床预后的指标之一。更多还原

【Abstract】 [Objective] To investigate correlation of dentritic cells (DCs) infiltration in uterine cervical carcinoma and pathological characterization and its effect on prognosis. [Methods] DCs infiltration density from 85 uterine cervical squamous carcinoma and 119 pelvic lymph notes were examined with SP immunohistochemistry method. [Results] Infiltration density of DCs in uterine cervical carcinoma was related to clinical stage, tumor differentiation, pelvic lymph notes metastasis(P <0.05), and had no correlation to infiltration of lymph vessels and blood vessels (P >0.05). DCs infiltration density in primary site of cervical carcinoma and non-metastatic pelvic lymph notes was related to prognosis (P <0.05). [Conclusion] DCs infiltration reflects immunological function of cervical carcinoma patients. Measurement of DCs infiltration is a parameter estimating prognosis of uterine cervical carcinoma patients.更多还原