【摘要】 目的探讨充血性心力衰竭(CHF)患者的血浆内皮素(ET-1)、一氧化氮(NO)和肿瘤坏死因子-α(TNF-α)的变化及卡维地洛对其影响。方法采用放射免疫法和比色法分别测定66例CHF患者和24例健康者(对照组)的血浆内皮素(ET-1)、肿瘤坏死因子-α(TNF-α)和一氧化氮(NO)浓度。66例CHF患者随机分为两组:A组30例,给予常规抗心力衰竭治疗;B组在常规治疗的基础上加用卡维地洛。两组治疗3个月。结果CHF组ET-1、TNF-α、NO水平显著高于对照组(P<0.01);CHF患者治疗后心功能均有改善,而B组治疗后ET-1、TNF-α、NO下降明显(P<0.01)。结论ET-1、TNF-α、NO与心力衰竭的发生发展有关,卡维地洛可降低CHF患者的ET-1、NO、TNF-α,从而改善心功能。更多还原

【Abstract】 [Objective] To study the levels changes of plasma tumor necrosis factor-alpha(TNF-α),endothelin-1(ET-1)and nitric oxide(NO)and the interv-ention role of dilatrend in patients with congestive heart failur(CHF).[Methods] TNF-α,ET-1 and NO levels were measured in 62 patients with CHF and 20 healthy subjects served as normal controls.62 patients with CHF were randomized into to A group of 32 cases and B group of 30 cases.A group were given cardiotonic,diuretic and extending blood vessel drugs;B group were given dilatrend 6.25 mg twice a day in the duration of three months,besides the medications admini-stered by A group.[Results] The serum TNF-α,ET-1 and NO levels in patients of CHF were much higher than those in normal subjects(P <0.01).Both of the therapies were effective in improving the symptoms of CHF,but only the atients treated with dilatrend lowered serum TNF-α,ET-1 and NO levels(P <0.01 or P <0.05).[Conclusion] These findings indicate that TNF-α,ET-1 and NO play an important role in the pathophysiologic changes of CHF.Dilatrend may decrease the levels of TNF-α,ET-1 and NO in patients with heart failure and improve the dysfunction of endothelial system.更多还原