【摘要】 目的探讨结缔组织生长因子(CTGF)在口腔黏膜下纤维性变(OSF)发病机理中的作用。方法应用原位杂交法对34例OSF、10例正常口腔黏膜组织角质形成细胞(KC)中CTGFmRNA进行检测。结果24例(70.6%)OSF组织KC中有CTGFmRNA表达,早期OSF组织KC中CTGFmRNA阳性表达明显高于中晚期OSF(P<0.05),10例正常口腔黏膜组织KC中CTGFmRNA表达呈阴性。结论OSF组织KC可合成分泌CTGF,在OSF发病机理中CTGF可能起重要作用,CTGF可能作为一中间介质参与了OSF的发病过程。更多还原

【Abstract】 [Objective] To investigate the significance of connective tissue growth factor(CTGF)in the pathogenesis of oral submucous fibrosis(OSF).[Methods] CTGF mRNA in keratinocyte(KC)of the paraff in embeded tissues of 34 cases OSF,10 normals were determined by the in situ hybridization technique.[Results] There was an expression of CTGF mRNA in KCs of 24 OSFs(70.6%).The positive expression of CTGF mRNA was higher in KCs of early stage OSF than that of middle and advanced stage(P <0.05).There was no expression in that of 10 normal tissues.[Conclusions] KC of OSF tissue may synthesize and release CTGF which may play an important role in the pathogenesis of OSF.CTGF may participate as a mediator in the fibrotic process of OSF.更多还原