【摘要】 目的探讨低密度脂蛋白受体(LDL-R)基因和载脂蛋白(Apo)CⅢ基因多态性与动脉粥样硬化性脑梗死(ACI)的关系。方法用聚合酶链反应(PCR)技术检测了中国辽宁籍汉族健康人104例和ACI患者77的LDL-R基因NcoⅠ、apoCⅢ基因SacI多态性及血脂、脂蛋白含量。结果对照组N+及S+等位基因频率为0.667、0.274;ACI组为0.662、0.329,差异无显著性(P>0.05),但ACI组S-S+与N-N+N+N+联合存在时的频率为0.45,显著高于对照组(P<0.05),致ACI的发病相对风险率(RR)为4.2(P<0.05),致血清TG、TC、LDL-C升高的RR依次为14.30、9.40、17.40。结论LDL-R基因N-N+N+N+、apoCⅢ基因S-S+联合存在与ACI患者血清高TG、高TC、高LDL-C相关,可能是致ACI的遗传易患因子。更多还原

【Abstract】 [Objective] To investigate the relationship between polymorphism of LDL receptor gene NcoⅠ and ApoC-Ⅲ Gene SacⅠand atherosclerotic cerebral infarction (ACI). [Methods] We measured the polymorphism of LDL-R gene NcoⅠand ApoC-Ⅲ gene Sac I with PCR method and the level of blood lipid and lipoprotein in 104 healthy controls and 77 ACI patients who are all Han nationality in Liaoning province of China. [Results] The allele frequency of N+ and S+ in the control and ACI group was 0.667, 0.274 and 0.662, 0.329 respectively. There was no significant difference between the two groups (P >0.05). The frequency of coexistence of S+ and N+ in ACI qroup was 0.45 and the relative risk (RR) leading to ACI was 4.20, which was significantly higher than that of control group (P <0.05). RR leading to high level of TG,TC and LDL-C was 14.30, 9.40, 17.40 respectively. [Conclusion] The coexistence of N+ of LDL-R gene and S+ of ApoC Ⅲ gene can raise the level of blood lipid and lipoprotein and might be a genetic factor of ACI.更多还原