【摘要】 目的探讨原发性干燥综合征(primarysjogrensyndrome,PSS)肝损害中各项肝功能指标的异常情况及有关资料,总结其肝损害特点。方法对194例明确诊断的原发干燥综合征的肝损害进行分析。结果194例符合FOX分类标准的干燥综合征直接造成的肝损害共52例(26.8%),其中各项指标异常比例:谷草转氨酶(AST)33例(63.5%),谷丙转氨酶(ALT)26例(50.0%),碱性磷酸酶(ALP)35例(67.3%),γ-谷氨酰转肽酶(GGT)27例(51.9%),总胆红素(TBIL)18例(34.6%),直接胆红素(DBIL)23例(44.2%)。52例中行肝脏活检4例,病理结果:2例为慢性活动性肝炎,1例脂肪肝,1例不除外病毒性肝炎。结论原发性干燥综合征直接肝损害率26.8%,其中既有胆管炎的表现,也有以肝细胞损害为主者。首发症状表现不一,应引起重视。更多还原

【Abstract】 [Objective] To analyze the abnormal levels of liver function of hepatic lesion in primary sjogren syndrome (pSS). And to summarize the characteristic of hepatic lesion. [Method] Hepatic lesion in 194 cases who were definitely diagnosed pSS were analyzed. [Results] Hepatic lesion in 52 cases (26.8%) were directly made among 194 cases which were diagnosed pSS according to FOX classified criterion. The abnormal proportion of each level were aspartclte aminotransferase (AST) 33 cases (63.5%), alanine aminotransferase(ALT) 26 cases (50.0%), alkaline phosphatase (ALP) 35 cases (67.3%), γ-glutamytransferase (GGT) 27 cases (51.9%), Total bilirubin (TBIL) 18 cases (34.6%) and direct bilirubin (DBIL) 23 cases (44.2%). 4 cases were made liver biopsy: 2 cases were chronic active hepatitis, 1 case was fatty liver, and 1 case could not be excluded viral hepatitis. [Conclusion] The ratio of direct hepatic lesion in pSS is 28.4%. Some have grading of cholangitis and some of them have hepatocellular lesion. The first symptom is not identical which should be emphasized.更多还原