【摘要】 目的观察辛伐他汀治疗老年高脂血症,特别是高胆固醇血症的疗效和安全性。方法选取58名老年高脂血症患者应用辛伐他汀20mg/d治疗,每3个月检查血脂、血尿常规、肝肾功能、肌酸激酶等生化指标1次,随访至少24个月,观察其调脂疗效和不良反应。结果辛伐他汀能使总胆固醇(TC)平均下降26.30%,低密度脂蛋白胆固醇(LDL-C)平均下降28.63%,甘油三酯(TG)平均下降16.38%,高密度脂蛋白胆固醇(HDL-C)平均上升8.16%;在随访期间,未发现有明显的不良反应出现。结论辛伐他汀有明显降低TC、LDL-C的作用,对TG也有一定降低作用,HDL-C则有一定升高作用;该药长期应用具有良好的安全性。更多还原

【Abstract】 [Objective] To evaluate the efficacy and safety of simvastatin in hyperlipidemia of elder patients, especially in hypercholesterolemia. [Methods] 58 elder patients with hyperlipidemia were treated with simvastatin 20 mg/d, serum lipids, blood routine, urine routine, liver function, kidney function and CK were measured once every 3 months during at least two years. [Results] The simvastatin has reduced the levels of total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C) and triglycerides(TG) in average 26.30%, 28.63% and 16.38% respectively. The level of high-density lipoprotein cholesterol (HDL-C) was elevated in average 8.16%. The adverse reactions of simvastatin were not obvious during the follow-up. [Conclusions] Simvastatin significantly reduces TC and LDL-C, reduces TG and slightly increases HDL-C. A good safety was observed after long time application of simvastatin.更多还原