【摘要】 目的探讨人白细胞DR抗原(HLA DR)基因与动脉粥样硬化性脑梗死(ABI)免疫遗传的相关性。方法采用聚合酶链反应和顺序特异性引物(PCR SSP)基因分析方法,对31例ABI患者及30名无血缘关系健康人的HLA DR部分等位基因及亚基因进行检测分析。结果ABI组HLA DR B1*0301等位基因相对危险度(RR)=5.6842,明显高于其他位点,差异有显著性(P<0.05);其他HLA DR B1*各等位基因未见异常。结论HLA DR B1*0301等位基因可能为北方汉族ABI患者的致病易感基因或与其他基因相连锁而共同致病。更多还原

【Abstract】 Objective To evaluate the relationship between atherosclerotic brain infarction (ABI) and human leukocyte antigen DR (HLA-DR) gene at molecular level. Methods By using polymerase chain reaction- sequence-specific probe (PCR-SSP), gene special position of the HLA-Ⅱ DR alleles were determined in 31 patients and 30 healthy individuals as controls, all of them were inhabitants of Northeastern China. Results The HLA-DR B1~*0301 gene frequency in the group of ABI was obviously higher than that of control group (RR=5.684 2, P<0.05). Conclusion The HLA-DR B1~*0301 gene may be the susceptible gene of ABI in Northeastern China, or it may associate with other genes to produce the disease.更多还原