【摘要】 目的探讨乌司他丁对严重烧伤患者脏器功能的作用。方法将同时期严重程度相当的中度以上烧伤住院患者72例随机分为治疗组(n=36)和对照组(n=36)。对照组按烧伤常规治疗;治疗组在常规治疗的基础上加用乌司他丁,特重烧伤每次300kU,中重度烧伤每次200kU,每日2次,连续使用5~7d。两组创面均外用聚乙烯吡咯烷酮碘(聚维酮碘)软膏及解毒烧伤膏。检测两组患者治疗前后的血常规、肝功能(丙氨酸转氨酶)、肾功能(血尿素氮、血肌酐)、凝血指标(凝血酶原时间、国际标准化比值、活化部分凝血活酶时间、纤维蛋白原)、心肌酶(天冬氨酸转氨酶、乳酸脱氢酶、α羟丁酸脱氢酶、肌酸激酶及其同工酶)、肌钙蛋白、肌红蛋白、动脉血气分析、创面细菌培养等。结果应用乌司他丁患者均能平稳渡过休克期、感染期和围手术期,创面渗出、水肿减轻,28d病死率为0。治疗组和对照组中度烧伤患者各项检测指标比较差异均无显著性(P均>0.05),重度以上烧伤患者各项检测指标两组比较差异均有显著性(P均<0.05)。结论乌司他丁能有效保护严重烧伤患者的脏器功能,适用于严重烧伤的急救治疗。更多还原

【Abstract】 Objective To investigate the protective effects of ulinastatin on organ function in severe burn. Methods Seventytwo cases with comparative severity in burn injury were randomly divided into ulinastatin treatment group (n=36) and control group (n=36). Patients in control group received routine therapy, while those in treatment group received intravenous dripping of ulinastatin twice a day for 5 to 7 days. The dosage of ulinastatin was 300 kU in severe burns and 200 kU in moderate burns. Both polyvinylpyrrolidone iodine (PVPI) and Jiedu Shaoshang cream (解毒烧伤膏) were used for wound dressing. The clinical findings were assessed and variables indicating functions of internal organs, including liver (alanine aminotransferase), kidney (blood urea nitrogen, serum creatinine), heart (aspartate aminotransferase, lactate dehydrogenase, αhydroxybutyrate dehydrogenase, creatine kinase, isoenzymes of creatinine kinase), and coagulation (prothrombin time, international normalized ratio, activated partial thromboplastin time, fibrinogen), as well as blood routine test, troponin, myoglobin, arterial blood analysis, bacteria culture were measured. Results In treatment group, vital signs and general condition were satisfactory at shock phase and perioperative stages in all the patients. Edema of burn wound subsided rapidly. The 28day mortality rate was 0. There was significant difference between the two groups (all P<0.05). Conclusion Ulinastatin has protective effects on multiple organs in severe burn injury.更多还原