【摘要】 目的调查中国广东地区乙型肝炎病毒(HBV)基因型,主要是基因亚型的分布情况。方法应用聚合酶链反应-限制性片段长度多态性法以及序列测定法,对广东地区417例慢性HBV感染者血清进行研究。结果广东地区流行的HBV基因型主要为B型和C型,其中B型为Ba亚型,未发现Bj亚型的存在。C亚型有C1和C2两个亚型,其中C1占63%,C2占37%。结论广东地区流行的HBV基因型以Ba和C1亚型为主,C2亚型较少,Bj亚型极为罕见。更多还原

【Abstract】 Objective To investigate the distribution of HBV genotype, especially HBV subgenotype in Guangdong province. Methods Serum samples from 417 patients with chronic HBV infection were included in this study. All samples were from patients in Guangdong province. The genotypes and subgenotypes of all samples were determined with nucleotide sequence analysis or polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results In Guangdong province, the most prevalent HBV genotypes are B and C. All genotype B strains belong to subgenotype Ba and subgenotype Bj was not found. For genotype C, two subgenotypes: C1 and C2 were identified. C1 accounted for 63% and C2 accounted for 37% of all HBV genotype C infected patients. Conclusion In Guangdong province, the prevalence of HBV subgenotypes Ba and C1 were more often than C2, subgenotype Bj was not found.更多还原