【摘要】 目的:比较氯诺昔康和曲马多对颌面部手术病人术后镇痛作用及不良反应。方法:40例颌面部手术病人随机分为两组,Ⅰ组(n=20)氯诺昔康组,Ⅱ组(n=20)曲马多组,均采用澳美电子镇痛泵PCA,其内设置和控制的参数有:(1)持续剂量:2ml/h;(2)锁定时间:20min;(3)PCA剂量:1ml。分别于术后12h、24h、36h、48h随访观察镇痛效果(VAS法)、镇静程度(Ramsay评分)、按压次数以及呼吸抑制、恶心呕吐、头昏等副作用。结果:两组病人VAS评分分别为2.1±1.6和2.5±1.7(P>0.05),镇痛效果差异无显著性意义。氯诺昔康组术后恶心例数为2例,曲马多为8例(P<0.01);呕吐例数分别为1例和4例。结论:氯诺昔康和曲马多均可于颌面部病人术后镇痛,而氯诺昔康镇痛效果更好,不良反应轻,是颌面部手术患者较为理想的术后镇痛模式。更多还原

【Abstract】 Objective: To compare the analgesic efficiency and adverse drug reactions of patient-controlled intravenous analgesia(PCIA) with Lornoxicam and Tramadol in patients undergoing the operation in cranio-cervical region.Methods: Forty ASAⅠ～Ⅱadult patients,who undergoing the operation in cranio-cervical region were randomly divided into two groups,both of which were diluted into 100ml with sodium and background 2ml/h,lockout time 15min,PCA bolus 0.5ml.The efficiency of analgesia provided by PCA was assessed by:(1)visual analogue scale(VAS) at 12,24,36h,48h after the operation;(2)adverse drug reactions such as nausea and vomiting,dizziness,respiratory depression and so on.Results: There was no statistically significant difference between the two groups in VAS score(P>0.05),There were 2 cases of nausea and one case of vomit in Lornoxicam group,as compared with 8 cases of nausea and 4 cases of vomit in Tramadol group.The number of nausea is 2 vs 8(P<0.01),voimiting 1 vs 4 in the two groups.Conclusion: Both lornoxicam and tramadol can be used in postoperative analgesia for patients undergoing oral maxillofacial surgery,of which lornoxicam has a better analgesia effect with less side effect and is a preferable choice.When used in patient-controlled intravenous analgesia,Lornoxicam has a safe and effect.condition,It can decrease the occurrence of side-effect each other when used with tramadol,especially nausea and vomit.更多还原