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盐酸左氧氟沙星氯化钠注射液与异烟肼注射液配伍稳定性考察

Compatibility stability of levofloxacin hydrochloride and sodium chloride injection with isoniazid injection

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【作者】 蒋海军张婷李新中

【Author】 Jiang Hai-jun~1,Zhang Ting~2,Li Xin-zhong~2(1.Department of Pharmacy,Changsha Central Hospital,Changsha 410008;2.Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410004)

【机构】 长沙市中心医院药剂科中南大学湘雅医院药剂科中南大学湘雅医院药剂科 长沙410004长沙410008

【摘要】 目的考察盐酸左氧氟沙星氯化钠注射液与异烟肼注射液配伍稳定性。方法在25℃、37℃条件下6 h内,观察盐酸左氧氟沙星氯化钠注射液与异烟肼注射液配伍后其外观、pH的变化,并用紫外分光光度法测定盐酸左氧氟沙星和异烟肼的含量。结果配伍液在6 h内其外观、pH及含量均无明显变化。结论在25℃、37℃条件下6h内盐酸左氧氟沙星氯化钠注射液与异烟肼注射液配伍基本稳定。

【Abstract】 OBJECTIVE To determine the compatibility stability of levofloxacin hydrochloride and sodium chloride injection with isoniazid injection.METHODS The contents of levofloxacin and isoniazid were detected by UV spectrophotometry and the appearance change and pH values were observed after both drugs were mixed within 6 h under(25 ℃) and 37 ℃.RESULTS These parameters of the mixed solution showed no significant change within 6 h.CONCLUSIONS It is stable within 6 h under(25℃) and 37 ℃after the drugs were mixed.

  • 【文献出处】 中南药学 ,Central South Pharmacy , 编辑部邮箱 ,2006年01期
  • 【分类号】R942
  • 【被引频次】5
  • 【下载频次】87
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