【摘要】 目的:检测肝硬化伴有不同程度肾功能损害的患者的血清C-反应蛋白(CRP)水平,探讨其在肝肾综合征(HRS)中的临床意义。方法:测定90例肝硬化病人和26例健康体健者的血清CRP水平,同时检测其肾功能。并分析CRP与肌酐清除率(Ccr)的关系。结果:CRP在肝硬化不同程度肾功能损害患者均较正常组明显升高,且随着肾功能衰竭的加重有逐渐升高的趋势,并与Ccr成负相关。结论:肝硬化患者血清CRP水平可反映肝硬化肾功能损害的程度,并有助于判断HRS病情及预后。更多还原

【Abstract】 Objective:to assess the levels of serum C-reactive protein(CRP) in cirrhotic patients with varied renal dysfunction and to investigate the relationship with HRS.Methods:The concentrations of CRP were quantitatively assessed in 90 cirrhotic patients and 26 normal age and sex-matched controls.Serum creatinine(Scr),blood urea nitrogen(BUN),liver function,prothrombin time and urea creatinine(Ucr) were assayed.The relativity of CRP to creatinine clearance rate(Ccr) was analyzed.Results: In cirrhotic group with renal dysfunction,the serum CRP levels were significantly higher than those in normal control group and cirrhotic group without renal dysfunction,and increased with the aggravated degree of renal dysfunction,Serum CRP concentrations inversely correlated with the Ccr(r=-0.631,P<0.01).Conclusions: The concentrations of CRP reflect the severity of HRS,and may be as an important indicator of prognosis in monitoring the patient’s condition.更多还原