【摘要】 目的:比较氟西汀和阿米替林治疗脑卒中后抑郁(PSD)的疗效和安全性。方法:将75例有脑卒中病史且符合CCMO-3中抑郁症诊断标准的患者随机分为两组,其中用氟西汀治疗37例(研究组),阿米替林治疗38例(对照组)进行6 W的双盲对照研究,于治疗前及治疗第2、4、6 W末采用汉密尔顿抑郁量表、临床总体量表-疗效总评量表评定临床疗效,副反应量表评定药物不良反应。结果:两组治疗第2 W末汉密尔顿抑郁量表评分较治疗前明显降低,两组间比较差异有显著性(P<0.05)。第6 W末两组间差异无显著性(P>0.05),氟西汀组的不良反应少且轻。结论:氟西汀不良反应小,起效快,服用安全,可以提高患者的依从性,更适用于PSD的治疗。更多还原

【Abstract】 Objective:To compare the curative effects and safety of fluoxetine and amitiriptyline in the treatment of poststroke depression(PSD).Methods:75 patients with PSD were randomly assigned to research group(n=37,took fluoxetine) and control group(n=38,took amitriptyline),for 6 week double-blind controlled study;Clinical curative effects were assessed with the Hamitlon Depression Scale(HAMD) and Clinical Global Impression(CGI),and adverse reactions with the Treatment Emergent Symptom Scale before treatment and at the end of the 2nd,4th,6th week of treatment.Results: At the end of the 2nd week scores of HAMD of both the two groups significantly decreased and there were significant differences between the two groups(P<0.05).At the end of the 6th week,there was no significant difference between two groups(P>0.05).Adverse reaction of fluoxetine was milder and better.Conclusions: Fluoxetine has milder adverse reaction,faster effect,and higher safety.更多还原