【摘要】 目的:观察脂代谢指标、超敏C反应蛋白(hs-CRP)和血管性假性血友病因子(vWF)与冠状动脉病变的关系及其相关性。方法:经冠状动脉造影证实的急性冠脉综合征(ACS)患者74例,其中急性心肌梗死(AM I)32例,不稳定性心绞痛(UAP)42例,另选23例冠状动脉造影阴性者为对照组,测定其血清总胆固醇(TCHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(apoA1)、载脂蛋白B(apoB)、hs-CRP和血浆vWF水平。结果:AM I组和UAP组HDL-C和apoA1明显低于对照组、hs-CRP和vWF明显高于对照组。三支血管病变组hs-CRP和vWF明显高于单双支病变组,hs-CRP和vWF与血管病变支数呈正相关。结论:急性冠脉综合征患者HDL-C和apoA1降低、hs-CRP和vWF升高,且hs-CRP和vWF与ACS严重程度相关,可能是ACS发生的危险因素。更多还原

【Abstract】 Objective:This study is to evaluate the serum lipoprotein,high-sensitivity C-reactive protein(hs-CRP) and von Willebrand factor(vWF) which is used to predict the clinical severity in patients with acute coronary syndrome(ACS).Methods:total cholesterol(TCHO),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),apolipoprotein(apoA1),apolipoprotein(apoB),hs-CRP and vWF were measured in patients.Combined with coronary angiography,the clinical severity was assessed.Results: HDL-C and apoA1 were all significantly lower in AMI and UAP group,hs-CRP and vWF were all significantly higher in AMI and UAP group compared with control group,but there was no significant difference between AMI and UAP group.hs-CRP and vWF were in direct proportion to the number of injured coronary in patient with ACS.Conclusions: The present study indicates that serum HDL-C,vWF and hs-CRP may be a risk factor of coronary artery disease,vWF and hs-CRP can reflect the clinical severity,and may mark unstable atherosclerotic plaque in patients with coronary heart disease.更多还原