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慢性乙型肝炎患者外周血淋巴细胞CD8~+CD38~+的检测意义

The detection of CD8~+CD38~+ expression of peripheral blood lymphocyte in patients with chronic hepatitis B

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【作者】 邱莲女朱永泽周永列骆思媛李宏波

【Author】 QIU Lian-Nü, ZHU Yong-Ze, ZHOU Yong-Lie, LUO Si-Yuan, LI Hong-Bo.Central Laboratory Medical,Zhejiang Provincial People′s Hospital,Hangzhou 310014,China

【机构】 浙江省人民医院检验医学中心温州医学院台州医学院杭州市第六人民医院 杭州310014温州325000杭州310014临海318000

【摘要】 目的:通过测定慢性乙型肝炎患者外周血淋巴细胞CD8+CD38+的表达及门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、凝血酶原时间(PT),旨在为治疗慢性乙型肝炎提供有用的参考指标。方法:流式细胞术检测38例慢性乙型肝炎、14例肝硬化患者外周血淋巴细胞CD8+CD38+细胞的百分率;同时测定AST、TBIL和PT。结果:(1)慢性乙型肝炎组CD8+CD38+、CD38+细胞均明显高于正常组(P<0.01,P<0.01),肝硬化组CD8+CD38+、CD38+细胞均明显高于正常组(P<0.05,P<0.05)。肝硬化组CD8+CD38+、CD8+细胞均明显低于慢性乙型肝炎组(P<0.05,P<0.05)。(2)慢性乙型肝炎轻、中、重各组之间比较,中度组CD8+CD38+高于轻度组(P<0.05),重度组CD8+CD38+、CD8+、CD38+均高于轻度组(P<0.05,P<0.05,P<0.05);重度组CD38+高于中度组(P<0.05);肝硬化组CD8+CD38+均明显低于轻、中、重各组(P<0.05,P<0.01,P<0.01),肝硬化组CD8+低于重度组(P<0.01)。(3)慢性乙型肝炎患者AST、TBIL、PT不正常组CD8+CD38+均高于AST、TBIL、PT正常组。结论:慢性乙型肝炎患者CD8+CD38+细胞明显升高,表明慢性乙型肝炎患者细胞免疫处于异常激活状态,并与肝功能损伤有一定的相关性。慢性乙型肝炎患者外周血淋巴细胞CD8+CD38+的测定,对病情分析和诊断有一定的临床参考价值。

【Abstract】 Objective:To supply a reference measure,CD8+CD38+ expressin,AST,TBIL,PT were examined in patients with chronic hepatitis B.Methods:CD8+CD38+ expression of peripheral blood lymphocyte in 38 patients with chromic hepatitis B and 14 patients with liver cirrhosis were detected with flow cytometry. AST,TBIL,PT were also measured at the same time with instruments.Results:(1)CD8+CD38+ expression in patients with choronic hepatitis B and liver cirrcosis elevated significantly compared with those in normal controls. But CD8+CD38+ expression in patients with liver cirrhosis was lower significantly than those with chronic hepatitis B.(2)CD8+CD38+ expression in moderate chronic hepatitis B were higher than those in mild chronic hepatitis B. CD8+CD38+,CD8+,CD38+ expression in severe chronic hepatitis B were higher than those in mild chronic hepatitis B. CD38+ expression in severe chronic hepatitis B was higher than those in moderate chronic hepatitis B. CD8+CD38+,CD8+,CD38+ expression in liver cirrhosis was lower than those in mild,moderate,severe chronic hepatitis B. CD8+ expression in liver cirrhosis was lower than those in severe chronic hepatitis B.(3)CD8+CD38+ expression in patients under AST,TBIL,PT abnormal condition were higher than those in patients under AST,TBIL PT,normal condition.Conclusion:The increasing of CD8+CD38+ expression of peripheral blood lymphocyte in patients with chronic hepstitis B,reflect the fact that cell immunolgy was abnormally activated.There was a remarkable correlation on CD8+CD38+ and AST,TBIL,PT. To test expression of CD8+CD38+ of peripheral blood lymphocyte in chronic hepatitis B has very important clinical reference value on patient′s condition development and diagnosis.

【关键词】 慢性乙型肝炎CD8+CD38+肝硬化
【Key words】 Chronic hepatitis BCD8+CD38+Liver cirrhosis
  • 【文献出处】 中国免疫学杂志 ,Chinese Journal of Immunology , 编辑部邮箱 ,2006年08期
  • 【分类号】R512.62
  • 【被引频次】6
  • 【下载频次】133
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