【摘要】 目的:探讨血清基质金属蛋白酶-9(MMP-9)诊断子宫内膜异位症(EMs)术后复发的价值。方法:对69例曾行子宫内膜异位症手术治疗的患者在术后6~12个月采用酶联免疫吸附法(ELISA)检测血清MMP-9含量,同时取25例正常妇女做对照。并用腹腔镜检查69例患者术后有无复发。结果:腹腔镜下诊断69例患者中有22例复发,47例未见复发。复发组血清MMP-9含量252·21±17·90ng/ml,明显高于未复发组(31·26±1·84ng/ml)和正常对照组(12·93±0·57ng/ml)。复发组与未复发组及正常对照组比较,差异有统计学意义(P<0·01)。血清MMP-9对EMs复发的敏感性为91·6%,特异性为85·1%。结论:血清中MMP-9水平检测可作为诊断EMs术后复发一个较为敏感而特异的参考指标。更多还原

【Abstract】 Objective:To investigate the value of serum matrix metalloproteinases- 9(MMP-9) level in the diagnosis of recurrence of endometriasis(EMs) after operation.Methods:Sixty-nine patients who had a previous operations for endometriosis were recruited in the study from February 2002 to March 2005. All the patient were examined by laparoscopy 6-12 months later after surgery. The serum were collected from the 69 patients and 25 health women for MMP-9 level measurement. ELISA was used to measure the level of serum MMP-9.Results:Twenty-two recurrent patients were diagnosed by Laparoscopy. The level of serum MMP-9 were 252.21±17.90 ng/ml in patients with recurrent endometriosis, 31.26±1.84 ng/ml in patients without recurrent endometriosis, 12.93±0.57 ng/ml in women without endometriosis. There was a clinical significance between the recurrent endometriosis group and non-recurrent endometriosis group and health women. The sensitivity for detection of recurrent endometriosis was 90.9% and the specificity was 85.1% using serum MMP-9 profile.Conclusion:Serum MMP-9 measurement is a sensitive, specific and non-invasive methods for the diagnosis of recurrent endometriosis.更多还原