【摘要】 实验研究了两种抗氧化剂硫辛酸和N-乙酰半胱氨酸对饲喂高脂饲料大鼠血脂代谢及其抗氧化能力的影响。32只SD大鼠分成4组,分别是正常饲料对照组、高脂饲料组、高脂饲料+硫辛酸(0.1%)组和高脂饲料+N-乙酰半胱氨酸(0.1%)组。结果表明饲喂高脂饲料可导致大鼠实验性高脂血症,与高脂模型组相比,饲料中添加0.1%的硫辛酸和N-乙酰半胱氨酸可显著降低大鼠血清TG、TC、LDL-C的含量,使动脉粥样硬化指数降低(P<0.05),显著增加血清HDL-C的含量(P<0.05),显著提高血清LPL和HL的活性;使血清和组织T-AOC、SOD活性、GSH含量显著上升(P<0.05),MDA含量显著降低(P<0.05)。说明添加硫辛酸和N-乙酰半胱氨酸对饲喂高脂饲料大鼠的血脂水平有明显的调节作用,可有效抑制脂质过氧化,预防动脉粥样硬化的发生。更多还原

【Abstract】 In this work the effects of lipoic acid(LA) and N-acetylcysteine(NAC) on blood lipid metabolism,antioxidation capability of rats fed high-fat diet were explored.32 SD rats were divided into 4 groups: control group,high-fat group,LA group(0.1%) and NAC group(0.1%).The results show that high-fat diet can cause hyperlipidemia.The values of TG,TC,LDL-C,MDA in serum are decreased significantly in LA and NAC groups(P<0.05)and the content of HDL-C in serum increases significantly(P<0.05).In comparison with high-fat group,both activities ofLPL and HL increase,SOD in serum and contents of T-AOC,GSH in serum and tissue increase significantly in LA and NAC groups(P<0.05).Moreover,LA and NAC can decrease atherosclerotic index(AI).It is concluded that LA and NAC have the function of reducing blood lipid and anti-lipid peroxidation,and prevent from atherosis.更多还原