【摘要】 目的观察地氟醚吸入麻醉对胸部肿瘤患者术中心肌肌钙蛋白I和心肌酶的影响。方法选择按美国麻醉医师协会(ASA)分级标准Ⅰ￣Ⅱ级择期手术患者30例,随机分成3组,吸入1.0MAC(肺泡最小有效浓度)地氟醚、异氟醚和安氟醚。分别于麻醉前、吸入麻醉1h、停止吸入麻醉时采集静脉血,测定心肌肌钙蛋白Ⅰ(cTnI),肌酸激酶(CK),肌酸激酶同工酶(CK-MB),天冬氨酸氨基转移酶(AST),乳酸脱氢酶(LDH)。结果术前三组患者cTnI,CK,CK-MB,AST,LDH均在正常范围。停止吸入麻醉时,三组患者CK均显著升高,异氟醚组和安氟醚组的CK-MB亦升高(但仍在正常范围),三组间CK,CK-MB比较差异无统计学意义。cTnI,AST,LDH在组内各时段及组间相应时段比较差异均无统计学意义。结论胸部肿瘤患者术中吸入1.0MAC地氟醚和异氟醚、安氟醚一样不引起心肌损伤。更多还原

【Abstract】 Objective To investigate the effects of desflurane on cardiac troponin I (cTnI) and myocardial enzyme. Methods Thirty ASA Ⅰ~Ⅱpatients scheduled for selective operation were randomly divided into three groups of tenin each: Desflurane group(D group), Isoflurane group(I group) and Enflurane group(E group). Anesthesia was maintained with inhalation of 1.0MAC of desflurane, isoflurane, and enflurane in each group respectively. Blood samples were taken before anesthesia, 1 h after inhalation and at the end of inhalation for the determination of plasma cTnI, CK, CK-MB, AST and LDH activities. Results cTnI, AST, LDH, CK and CK-MB levels were normal before anesthesia. At the end of inhalation, CK increased significantly in three groups, CK-MB increased markedly in Enflurane group and Isoflurane group, but CK-MB level was normal in desflurane group. However, the CK-MB level was normal in all patients. cTnI, AST, LDH showed little changes during inhalation. Conclusions Inhalation of 1.0 MAC of desflurane, isoflurane and enflurane doesn’t result in myocardial injury.更多还原