【摘要】 目的评价全身热疗联合化疗对晚期非小细胞肺癌(NSCLC)的近期疗效及不良反应。方法实验组24例,其中男性16例,女性8例;初治18例,复治6例;Ⅲb期15例,Ⅳ期9例;初治患者采用全身热疗联合紫杉醇+卡铂方案,复治患者采用全身热疗联合单药多西他赛(商品名:泰索帝)方案,治疗1周期后,再采用同一方案化疗1周期。对照组26例,其中男性17例,女性9例;初治20例,复治6例;Ⅲb期16例,Ⅳ期10例;初治患者采用紫杉醇+卡铂方案,复治患者采用单药泰索帝方案,化疗2周期。3周为一个周期,完成2周期化疗后4周作疗效评价。结果实验组有效率为58.3%,对照组有效率为30.8%;常见毒副反应为胃肠道反应、神经毒性及骨髓抑制,但均可以耐受。结论全身热疗联合化疗治疗晚期NSCLC具有显著的治疗效果,并且毒副反应可以耐受。更多还原

【Abstract】 Objective To evaluate the efficacy and the side effects of whole body hyperthermia(WBH) combined with chemotherapy for the treatment of advanced non-small cell lung cancer. Methods 24 patients were included in trial group(16 male and 8 female), 15 patients in Ⅲb stage and 9 patients in Ⅳ stage.6 patients had received chemotherapy before, received 1 course of WBH combined with Docetaxel; 18 cases were previously untreated, received 1 course of WBH combined with Paclitaxel and Carboplatin, then another course chemotherapy in the same time period. 26 patients were included in control group (17 male and 9 female), 16 patients in Ⅲb stage and 10 patients in Ⅳ stage. 6 patients had received chemotherapy before, were treated with Docetaxel at least 2 courses with 3 weeks interval. 20 cases, previously untreated, were treated with Paclitaxel combined with Carboplatin at least 2 courses with 3 weeks interval. Efficacy was evaluated 4 weeks after 2 courses of chemotherapy. Results The response rate was 58.3, and 30.8 in control group. The common side effects were gastrointestinal toxicity , nerve toxicity and leucopenia, but these side effects were all mild. Conclusions WBH combined with chemotherapy is an effective regimen for the treatment of advanced non-small cell lung cancer with acceptable toxicity.更多还原