【摘要】 目的探讨新疆地区维吾尔族女性乳腺癌的发病特点、临床与病理特征及其与预后的关系。方法对74例有完整病例资料及随访的维吾尔族女性乳腺癌患者的临床病理资料进行多因素COX回归分析。结果74例维吾尔族女性乳腺癌3年生存率和5年生存率分别为75.00%(48/64)和43.50%(2/046),经多因素COX回归分析显示,年龄、月经状况、淋巴结转移、TNM分期及PR表达5项指标反应维吾尔族女性乳腺癌的预后情况,危险度分别为0.037,0.103,13.851,18.877和0.046。结论新疆维吾尔族女性乳腺癌患病的比重小,但发病年龄较早,以36～50岁多见,且以Ⅱ,Ⅲ期居多,预后较差。年龄、月经状况、淋巴结转移、TNM分期、PR表达是影响维吾尔族女性乳腺癌预后的独立指标。早诊断、早治疗是提高其生存率的关键。更多还原

【Abstract】 Objective To explore the clinical trait and relationship between clinicopathological characteristics and prognosis in Uygurs women with breast cancer of Xinjiang. Methods The clinicopathological data of 74 cases with breast cancer of Uygurs women were analyzed, multivariate analysis was done by COX proportional hazard model. Results 74 cases have followed up: there-year and five-year survival rates were 75.00 %(48/64) and 43.50 %(20/46)respectively. Multivariable COX regression revealed that patient age, menstruation, status of involved lymph node, TNM and the expression of PR were five important and independent prognostic factors for breast cancer of Uygurs women, the hazard rations of these factors were 0.037, 0.103, 13.851, 18.877, and 0.046, respectively. Conclusions The proportion of breast cancer of Uygurs women was low in patient of Xinjiang, but patient age was young, age of onset were more than half between 36 and 50 years old and mainly belong to Ⅱ, Ⅲ stage of TNM, prognosis was poorly. Patient age, menstruation, status of involved lymph node, TNM and the expression of PR serve as independent prognostic indexes of breast cancer of Uygurs women. Early diagnosis and treatment are very important to improve the survival rate of breast cancer patients更多还原