【摘要】 目的观察消癌平-生长抑素类似物(SSA)联合治疗难治性卵巢癌的初步临床效果。方法9例晚期卵巢癌患者分为A、B两组,A组给予消癌平-奥宁治疗(2例补充了化疗),B组给予消癌平+化疗治疗。采用影像学+体检评估治疗效果,比较肿瘤组织生长抑素受体2(SSTR2)和肿瘤标志物治疗前后的变化与疗效的关系。结果A组7例,可观察的实体瘤(CR+PR)为29%,5例合并腹腔积液(CR+PR)为80%,给予补充化疗的2例患者中,1例因腹腔积液SSTR2(-),腹腔用DDP治疗2次,达CR,另1例因首次治疗NC,第2周期加用化疗达PR。B组2例,1例CR、1例PR。全部患者的临床受益疗效(CBR)较高。SSTR2表达与疗效比较符合率达71%(5/7)。但肿瘤标志物治疗前后变化不显著。随诊结果除1例于休息阶段死亡外,其余均接受了再次治疗。结论消癌平-生长抑素类似物治疗难治性卵巢癌有确切疗效,合并应用化疗可使抗肿瘤作用获得互补。推测这是有别于化疗的一种新的肿瘤内科治疗方法,其抗肿瘤机制可能是抑制癌细胞增生及加快其凋亡。更多还原

【Abstract】 Objective Introducing a new discovery in cancer therapy versus a clinical study on treating intractable ovarian cancer with Xiao’ aiping-SSA(Somatostatin Analogue). Methods Divide 9 patients with intractable ovarian cancer into two groups. A:Xiao’ aiping-SSA group; B: Xiao’ aiping plus combined chemotherapy group. According to the result of somatoscopy and medical imaging examination, the therapeutic effect was determined, and the interrelation of SSTR2 of tumor tissues and change of tumor marker before and after application of chemotherapy was compared. Results Group A: 7 patients, among them, the therapeutic effect of the tumor: CR+PR=29 %; the therapeutic effect of ascites: CR+PR=80 %; among 2 patients who receive chemotherapy, one receive intraperitoneal therapy with DDP(because SSTR2 of cancer cell was negative in the ascites), the therapeutic effect is CR, the other is PR after receiving combined chemotherapy(who first therapeutic effect is NC with Xiao’ aiping - SSA). Group B: 2 patients, their therapeutic effect is CR and PR. All patients’ CBR(Clinical Benefit Response)was very good. The relativity of therapeutic effect and the SSTR2 approached in 71% (5/7). There are of no significant differences in the tumor markers before and after the treatment. Following up: All patients received the therapy except one who was died from intestinal obstruction during break period. Conclusion There were a good therapeutic effect in the patients suffering from intractable ovarian cancer and receiving the treatment of Xiao’ aiping-SSA, and SSTR2 is positive and having received ineffective chemotherapy. Combined Xiao’ aiping-SSA plus chemotherapy complemented and enhanced in the effect of anti-tumor. We suppuse that it is different to combined chemotherapy in the effect of anti-tumor. The anti-tumor effect may be by controlling the proliferation and promoting apoptosis of cancer cells.更多还原