【摘要】 目的观察甲状腺嗜酸细胞肿瘤(HCT)的临床病理学特点。方法对16例甲状腺HCT进行临床病理学分析和免疫组化研究,并结合文献进行分析。结果16例中13例嗜酸细胞腺瘤,3例嗜酸细胞腺癌,肿瘤以细胞质嗜酸性、粗颗粒为特点,细胞形态多样,排列成滤泡型、小梁型和实体型。良性和恶性HCT表达TG,S-100,Vim无差异。结论甲状腺HCT是有独特病理形态特点且具有潜在恶性的肿瘤,对其生物学行为应长期跟踪随访,免疫组织化学和电镜不能区别良、恶性,主要依靠传统的包膜、血管浸润或远处转移。更多还原

【Abstract】 Objective Investigate the clinicopathological characteristics of hürthle cell tumors of the thyroid. Methods Sixteen cases of HCT were studied by the clinicopathological study and immunohistochemical and review of the literature. Results There were 13 cases of hürthle cell adenomas, 5 hürthle cell follicular carcinomas. Immunostains showed that almost all benign and malignant HCT expressed TG, vimentin, S-100 protein. Conclusions HCT is a potential malignant tumor with a defined pathologic feature. It should be follow up for a longer time to their biological behaviors. To distinguish between the benign and the malignant depends on traditional encapsulation, and whether there is a blood vessel invasion or metastasis.更多还原