【摘要】 目的探讨阿尔茨海默病(AD)与血清胆固醇、血脂、VB12、叶酸和甲状腺激素的关系。方法对35例AD和16例健康对照组血清胆固醇、血脂、VB12、叶酸及甲状腺激素进行测定,并进行组间对比研究。结果AD组血清胆固醇、甘油三酯明显高于对照组(P<0.05);AD组和正常对照组的血清VB12和叶酸水平相比无显著性差异(P>0.05);AD组TT4水平明显高于对照组(P<0.01),而TT3和TSH两组间无显著性差异(P>0.05)。结论血清总胆固醇和甘油三酯增高与AD有明显的关系,AD血清叶酸及VB12无明显变化,甲状腺功能异常可能与AD发病有关。提示降低胆固醇及血脂可能会对AD预防和治疗有益。更多还原

【Abstract】 Objective To investigate the relationship among change of serum cholesterol,lipid,VB₁₂ and folate acid and（Alzheimer’s） disease（AD）.Methods Serum concentrations of cholesterol,lipid,VB₁₂,folate acid and thyroid hormones in 35 patients with AD and 16 normal controls were detected and compared.Results The levels of serum cholesterol and triglyceride in AD group was higher than those of normal control group（P<0.05）;The levels of serum VB₁₂ and folate acid had no significant difference between two groups（P>0.05）.The levels of serum TT₄ in AD group was higher than that of normal control group（P<0.01）.The levels of serum TT₃ and TSH had no significant difference between two groups（P>0.05）.Conclusions The increased serum cholesterol and triglyceride levels may be obviously associated with AD,but serum folate acid and VB₁₂ in AD have no significant changes.Abnormal thyroid function might be related to AD.These results suggest that decreased cholesterol and triglyceride may provide potential benefits of preventing and treating AD.更多还原