【摘要】 目的:探讨影响喉癌患者术后生存质量(QOL)的相关因素,并寻找提高其生存质量的方法。方法:38例喉癌全切除(A组)和21例部分切除(B组)术后的患者进行头颈肿瘤治疗功能性评估量表问卷调查,并比较2组患者总的生存质量和生存质量各个方面之间的差异,分析导致产生差异的相关因素。结果:B组生存质量总分及各个分项分(包括生理、社会家庭、情感、功能状况及附加关注得分)均高于A组(P<0.01、0.05)。影响喉癌患者术后生存质量的相关因素从大到小依次为放化疗、并发症、手术方式及疾病分期。结论:在彻底切除喉部癌症病变的前提下尽量选用喉部分切除术,保证患者生存率的同时使术后获得较高的生存质量。更多还原

【Abstract】 Objective: To evaluate the quality of life (QOL) following laryngectomy and the relevant factors influencing QOL.Methods: The QOL was evaluated in 38 patients undergoing total laryngectomy and 21 partial laryngectomy with the FACT-H&N questionnaire.All data were analyzed with t-test and multiple linear regression analysis.Results: The composite total QOL scores of patients with partial laryngectomy(110.4±16.3) were higher than those of patients with total laryngectomy(88.0±23.8),with a difference being statistically significant(P<(0.01)).Partial laryngectomy patients(24.2±3.3) were better than total laryngectomy patients(22.2±4.3,P<(0.05)) in physical well-being.In social/family well-being,emotional well-being,functional well-being and additional concerns partial laryngectomy patients(22.1±4.6;20.5±3.9;19.5±4.6;23.5±5.5) were also better than total laryngectomy patients(16.8±7.2;16.3±5.7;14.7±6.8;17.9±5.0,P<0.01).Radiotherapy or/and chemotherapy,complication,operative modality and stage were related to postlaryngectomy QOL.Conclusion: FACT-H&N questionnaire is suitable for QOL research for laryngeal cancer in China.The QOL of patients with partial laryngectomy are better than that of patients with total laryngectomy.In the condition of thoroughly cut laryngeal cancer,partial laryngectomy is superior to total laryngectomy in QOL.更多还原