【摘要】 目的:对已发现的几种淋巴管特异性标记物在人类多种肿瘤中的表达进行观察,从而找出适合于肿瘤组织淋巴管研究的标记物。方法:取人结肠癌、肺癌、胃癌和喉癌手术材料,免疫组化法观察LYVE-1、Podoplanin和VEGFR-3在癌组织的表达。结果:LYVE-1只表达于淋巴管内皮,Podoplanin主要表达于淋巴管,此外在少数小静脉上也有表达,VEGFR-3则同时表达于淋巴管与小血管,在癌细胞的胞浆中也可呈阳性表达。结论:LYVE-1、Podoplanin可以作为肿瘤组织内淋巴管的特异标记物。更多还原

【Abstract】 Objective: To observe the expression of three kinds of special markers of lymphatics in human tumor for choosing the most available special lymphatic marker in tumor tissues. Methods: Immunohistochemistry methods were used in human gastric cancer, lung cancer, colon cancer and larynx cancer to observe the expression of LYVE-1, Podoplanin and VEGFR-3. Results: LYVE-1 only expressed in lendothelial tissue of lymphatic vessels, Podoplanin expressed mainly in lymphatic vessels and a few of small veins, however, VEGFR-3 expressed in both lymphatic and small blood vessels. The positive expression of VEGFR-3 could also be found in kytoplasm of cancer cells. Conclusions: LYVE-1 and Podoplanin can be used to identify lymphatic and blood vessels in tumor tissues.更多还原