【摘要】 目的:探讨聚磷酸钙纤维(calciumpolyphosphatefiber,CPPF)和磷酸钙骨水泥(calciumphosphatece-ment,CPC)复合材料修复骨缺损的能力及作为人工骨修复替代材料的可行性。方法:选用新西兰大白兔双侧桡骨制作骨缺损模型,将CPPF/CPC复合材料植入左侧骨缺损处,右侧骨缺损以自体微小颗粒骨植入作为实验对照,另做不植入任何物质的骨缺损作空白对照。在2、4、8、12周时分别进行大体观察、X线摄片、组织学切片观察,8、12周时进行扫描电镜观察及骨密度测定,12周时进行力学测试。结果:CPPF/CPC人工骨组与微小颗粒骨组骨缺损均完全修复,空白对照组骨缺损未见修复,CPPF/CPC与微小颗粒骨两组间X线评分、骨密度及力学测试指标比较,差异均无统计学意义(P>0.05)。结论:CPPF/CPC复合材料具有良好的骨传导能力、力学特性及生物相容性,有望成为骨组织工程中修复骨缺损的理想材料。更多还原

【Abstract】 Objective:To evaluate the ability of calcium polyphosphate fiber(CPPF) and calcium phosphate cement (CPC) in repairing bone defects and discuss the feasibility of composite of CPPF/CPC as bone substitution materials.Method:The animal models of bilateral radius bone defects were established in the New Zealand white rabbits,the composite of CPPF/CPC was implanted on the left bone defect (experimental group) while left micromorselized bone on the right defects(experimental control group).The bone defects with no implant were used as blank control group.The effect was analyzed by gross observation,X-ray and histopathological test at 2?4?8?12 weeks after operation respectively.In the meantime,the interface between implants and receptor bone and bone density were observed by the scanning electron microscope at 8?12 weeks,biomechanics tests were performed at 12 weeks after operation.Result:The defects in experimental group and experimental control group got thorough repaired.There was no statistical significance between experimental group and control group upon biomechanics(P>0.05).Conclusion:Composite of CPPF/CPC has good biocompatibility and osteoconductive ability and may be one of the ideal materials in repairing bone defects.更多还原